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Mammalian Cell Designers’ Laboratory

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Engineering programmable
mammalian cell factories
for next-generation biotherapeutic production

Research Topic

Research

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Cell Line Development/Cell Engineering
RESEARCH 01

Cell Line Development
Cell Engineering

Programmable mammalian cells

Secretory pathway engineering

Functional genomics
Autonomous Lab
RESEARCH 02

Autonomous Lab

Laboratory automation

High-throughput phenotyping

DBTL platforms
Biopharmaceutical Manufacturing
RESEARCH 03

Biopharmaceutical Manufacturing

Production host engineering

Advanced biologics manufacturing

Data-driven bioprocess optimization

Selected Publications

Publication

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2026
Quantitative Proteomics and CRISPR/Cas9 Editing Reveal UPR‐Mediated Control of Immunoglobulin Homeostasis in Hybridomas

Rubing Zou*, Xinying Lu*, Ying Liu, Peiyu Yang, Shuo Sun, Yihua Liu, Yinyuan Mo, Guonian Zhu, Jae Seong Lee‡, Yirong Guo‡, Advanced Science, 13(17):e14140
2025
CRISPR screen-based mammalian cell engineering for complex biotherapeutics

Sung Wook Shin*, Gyun Min Lee, Jae Seong Lee‡, Trends in Biotechnology, Epub ahead of print, S0167-7799(25):00464-0
2025
Comprehensive genome-scale CRISPR knockout screening of CHO cells

Sung Wook Shin*, Su Hyun Kim*, Aghiles Gasselin, Gyun Min Lee‡, Jae Seong Lee‡, Scientific Data, 12(1):71
2024
A precise and sustainable doxycycline-inducible cell line development platform for reliable mammalian cell engineering with gain-of-function mutations

Sung Wook Shin*, Honggi Min, Jiwon Kim, Jae Seong Lee‡, Metabolic Engineering, 86:12-28

News & Gallery

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news
2026.08.11
August 6, 2026 | Dr. Lee Gave a Seminar at Yonsei University (Department of Biotechnology)
news
2026.08.03
August 3, 2026 | Dr. Hyeonseon Park has joined the MCD Lab as a postdoctoral researcher. Welcome to the MCD Lab!
news
2026.05.15
May 14, 2026 | Jiwon Kim received the Excellent Paper Presentation Award at the 2026 KSIEC Spring Meeting. Congratulatio…
gallery
2026.08.05
박현선 박사님 환영회
gallery
2026.07.23
2026 MCD 여름 회식
gallery
2026.07.23
2026 ASK Summer Conference
gallery
2026.07.23
2026 스승의 날
gallery
2026.05.31
2026 KSIEC Spring Meeting
gallery
2026.04.15
2026 KSBB Spring Meeting
gallery
2026.04.06
2026 KAIST Strawberry Party