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Mammalian Cell Designers’ Laboratory

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Engineering programmable
mammalian cell factories
for next-generation biotherapeutic production

Research Topic

Research

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Cell Line Development/Cell Engineering
RESEARCH 01

Cell Line Development
Cell Engineering

Programmable mammalian cells

Secretory pathway engineering

Functional genomics
Autonomous Lab
RESEARCH 02

Autonomous Lab

Laboratory automation

High-throughput phenotyping

DBTL platforms
Biopharmaceutical Manufacturing
RESEARCH 03

Biopharmaceutical Manufacturing

Production host engineering

Advanced biologics manufacturing

Data-driven bioprocess optimization

Selected Publications

Publication

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2026
Quantitative Proteomics and CRISPR/Cas9 Editing Reveal UPR‐Mediated Control of Immunoglobulin Homeostasis in Hybridomas

Rubing Zou*, Xinying Lu*, Ying Liu, Peiyu Yang, Shuo Sun, Yihua Liu, Yinyuan Mo, Guonian Zhu, Jae Seong Lee‡, Yirong Guo‡, Advanced Science, 13(17):e14140
2025
CRISPR screen-based mammalian cell engineering for complex biotherapeutics

Sung Wook Shin*, Gyun Min Lee, Jae Seong Lee‡, Trends in Biotechnology, Epub ahead of print, S0167-7799(25):00464-0
2025
Comprehensive genome-scale CRISPR knockout screening of CHO cells

Sung Wook Shin*, Su Hyun Kim*, Aghiles Gasselin, Gyun Min Lee‡, Jae Seong Lee‡, Scientific Data, 12(1):71
2024
A precise and sustainable doxycycline-inducible cell line development platform for reliable mammalian cell engineering with gain-of-function mutations

Sung Wook Shin*, Honggi Min, Jiwon Kim, Jae Seong Lee‡, Metabolic Engineering, 86:12-28

News & Gallery

Board

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news
2026.04.21
Dr. Lee Gave a Seminar at Seoul National University (Bionanoengineering Seminar, Department of Mechanical Engineering)
news
2026.04.14
Mammalian Cell Designers’ Lab is actively recruiting a Postdoctoral Fellow

We are seeking highly motivated candidates interested in mammalian cell engineering–driven biopharmaceutical manufacturing, 

with backgrounds in mammalian cell engineering, synthetic biology, protein engineering, or AI/ML.

Our lab focuses on developing next-generation programmable mammalian cell factories for efficient and scalable production of therapeutic proteins.

Please send your CV to jaeseonglee@kaist.ac.kr
 

Refs. KAIST InnoCORE [5. 인공세포 기반 바이오 제조 혁신 연구단]
news
2026.03.31
The MCD Lab Website Has Been Renewed.

The MCD lab website has been renewed – Please check it out!
gallery
2026.04.15
2026 KSBB Spring Meeting
gallery
2026.04.06
2026 KAIST Strawberry Party